Skip to main content
Structure of dimeric lipoprotein lipase reveals a pore adjacent to the active site.

Kathryn H Gunn, Saskia B Neher.

Nature Communications. 2023 May

Combined action of albumin and heparin regulates lipoprotein lipase oligomerization, stability, and ligand interaction.

Robert RistiKathryn H GunnKristofer Hiis-HommukNatjan-Naatan SeebaHamed Karimi Ly VilloMarko VendelinSaskia B NeherAivar Lõokene.

PLoS One. 2023 April

Characterization of lipoprotein lipase storage vesicles in 3T3-L1 adipocytes.

Roberts, B. S., Yang, C. Q., & Neher, S. B.

Journal of Cell Science. 2022

Comparison of angiopoietin-like protein 3 and 4 reveals structural and mechanistic similarities.

Gunn, K. H., Gutgsell, A. R., Xu, Y., Johnson, C. V., Liu, J., & Neher, S. B.

Journal of Biological Chemistry. 2021

The structure of helical lipoprotein lipase reveals an unexpected twist in lipase storage.

Gunn K.H., Roberts, B.S., Wang F., Strauss J.D., Borgnia M.J., Egelman E.H., & Neher, S.B.

Proc Natl Acad Sci. 2020 April

A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides.

Wolska A., Lo L., Sviridov D.O., Pourmousa M., Pryor M., Ghoush S.S., Kakkar R., Davidson M, Wilson S, Pastor R.W., Goldberg I.J., Basu D., Drake S.K., Cougnoux A., Wu M.J., Neher S.B., Freeman L.A., Tang J., Amar M., Devalaraja M., & Remaley A.T.

Science Translational Medicine. 2020 January

Endoplasmic reticulum quality control in lipoprotein metabolism.

Koerner, C. M., Roberts, B. S., & Neher, S. B.

Molecular and Cellular Endocrinology. 2019

Protecting activity of desiccated enzymes.

Piszkiewicz, S., Gunn, K. H., Warmuth, O., Propst, A., Mehta, A., Nguyen, K. H., Kuhlman, E., Guseman, A. J., Stadmiller, S. S., Boothby, T. C., Neher, S. B., & Pielak, G. J.

Protein Science. 2019

Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition.

Gutgsell, A. R., Ghodge, S. V., Bowers, A. A., & Neher, S. B.

Journal of Biological Chemistry. 2019

Coexpression of novel furin-resistant LPL variants with lipase maturation factor 1 enhances LPL secretion and activity.

Wu, M. J., Wolska, A., Roberts, B. S., Pearson, E. M., Gutgsell, A. R., Remaley, A. T., & Neher, S. B.

Journal of Lipid Research. 2018

Lipase maturation factor 1 affects redox homeostasis in the endoplasmic reticulum.

Roberts, B. S., Babilonia‐Rosa, M. A., Broadwell, L. J., Wu, M. J., & Neher, S. B.

The EMBO Journal. 2018

We FRET so You Don’t Have To: New Models of the Lipoprotein Lipase Dimer.

Hayne, C. K., Yumerefendi, H., Cao, L., Gauer, J. W., Lafferty, M. J., Kuhlman, B., Erie, D. A., & Neher, S. B.

Biochemistry. 2018

Biochemical Analysis of the Lipoprotein Lipase Truncation Variant, LPLS447X, Reveals Increased Lipoprotein Uptake.

Hayne, C. K., Lafferty, M. J., Eglinger, B. J., Kane, J. P., & Neher, S. B.

Biochemistry. 2017

Modulation of the Activity of Mycobacterium tuberculosis LipY by Its PE Domain.

Garrett CK, Broadwell LJ, Hayne CK, Neher SB.

PLoS One. 2015 August

Purification, cellular levels, and functional domains of Lipase Maturation Factor 1.

Babilonia-Rosa, M. and Neher, SB

BBRC, 2014, July

Signal Recognition Particle-Ribosome Binding Is Sensitive To Nascent-Chain Length.

Noriega TR, Tsai A, Elvekrog MM, Petrov A, Neher SB, Chen J, Bradshaw N, Puglisi JD, Walter P.

J Biol Chem. 2014 May

Heat shock transcription factor σ(32) co-opts the signal recognition particle to regulate protein homeostasis in E. coli. 

Lim B, Miyazaki R, Neher S, Siegele DA, Ito K, Walter P, Akiyama Y, Yura T, Gross CA.

PLoS Biol. 2013 December

Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase: Evidence for Reversible Complex Formation

Lafferty MJ, Bradford KC, Erie DA and Neher SB

Journal of Biological Chemistry. 2013 October

Concerted Complex Assembly and GTPase Activation in the Chloroplast Signal Recognition Particle Biochemistry.

Nguyen TX, Chandrasekar S, Neher S, Walter P, Shan SO

Biochemistry. 2011 August

Signal sequences activate the catalytic switch of SRP RNA

Bradshaw N*, Neher SB*, Booth DA, Walter, P. *equal contribution

Science. 2009 January

SRP RNA controls a conformational switch regulating the SRP-SRP receptor interaction.

Neher SB*, Bradshaw N*, Floor S, Gross JD, Walter P. *equal contribution

Nature Structural and Molecular Biology. 2008 September

Ligand-controlled proteolysis of the Escherichia coli transcriptional regulator ZntR.

Pruteanu M, Neher SB, Baker TA.

J Bacteriol. 2007 April

Proteomic profiling of ClpXP substrates following DNA damage reveals extensive instability within SOS regulon.

Neher SB, Villen J, Oakes EC, Bakalarski CE, Sauer RT, Gygi SP, Baker TA.

Mol Cell. 2006 April

Sculpting the proteome with AAA(+) proteases and disassembly machines.

Sauer RT, Bolon DN, Burton BM, Burton RE, Flynn JM, Grant RA, Hersch GL, Joshi SA, Kenniston JA, Levchenko I, Neher SB, Oakes ES, Siddiqui SM, Wah DA, Baker TA.

Cell. 2004 October

Distinct peptide signals in the UmuD and UmuD’ subunits of UmuD/D’ mediate tethering and substrate processing by the ClpXP protease.

Neher SB, Sauer RT, Baker TA.

Proc Natl Acad Sci U S A. 2003 Nov 11

Latent ClpX-recognition signals ensure LexA destruction after DNA damage.

Neher SB, Flynn JM, Sauer RT, Baker TA.

Genes Dev. 2003 May

Proteomic discovery of cellular substrates of the ClpXP protease reveals five classes of ClpX-recognition signals.

Flynn JM, Neher SB, Kim YI, Sauer RT, Baker TA.

Mol Cell. 2003 March